| 09/07/2021 | Chesham United | Unofficial Friendly | | Away | D | 1-1 | 300 | | Trialists Match |
| 16/07/2021 | Beaconsfield United | Unofficial Friendly | | Home | W | 10-1 | | | Trialists Match |
| 17/07/2021 | Stevenage | Unofficial Friendly | | Home | W | 1-0 | | | BCD |
| 23/07/2021 | Aylesbury United | Unofficial Friendly | | Away | W | 3-1 | | | Trialists Match : At Chesham |
| 28/07/2021 | Leicester City | Friendly | | Home | W | 1-0 | ? | | |
| 30/07/2021 | Hanwell Town | Unofficial Friendly | | Away | W | 3-1 | | Connor Parsons (2), Alfie Stanley | Trialists Match |
| 07/08/2021 | Accrington Stanley | Sky Bet League 1 | | Home | W | 2-1 | 4551 | | |
| 10/08/2021 | Exeter City | Carabao Cup | 1 | Away | W | 0-0 | 2555 | | WW won 4-3 on Penalties |
| 14/08/2021 | Cheltenham Town | Sky Bet League 1 | | Away | W | 3-1 | 3860 | Sam Vokes 14, Olly Pendlebury 74,79 | |
| 17/08/2021 | Wigan Athletic | Sky Bet League 1 | | Away | D | 1-1 | 8671 | | |
| 21/08/2021 | Lincoln City | Sky Bet League 1 | | Home | W | 1-0 | 5032 | | |
| 24/08/2021 | Stevenage | Carabao Cup | 2 | Away | W | 2-2 | 1934 | Adebayo Akinfenwa 23, Tjay DeBarr 94 | WW won 5-3 on Penalties |
| 28/08/2021 | Sunderland | Sky Bet League 1 | | Away | L | 1-3 | 29,344 | | |
| 31/08/2021 | Aston Villa U21s | EFL Trophy | SGC | Home | L | 1-3 | 1409 | | |
| 09/09/2021 | Maidenhead United | Unofficial Friendly | | Home | L | 2-3 | 0 | Anis Mehmeti 2, Connor Parsons 85 | BCD |
| 11/09/2021 | Oxford United | Sky Bet League 1 | | Away | D | 0-0 | 9082 | | |
| 18/09/2021 | Charlton Athletic | Sky Bet League 1 | | Home | W | 2-1 | 5832 | | |
| 21/09/2021 | Manchester City | Carabao Cup | 3 | Away | L | 1-6 | 30,595 | | |
| 25/09/2021 | MK Dons | Sky Bet League 1 | | Away | L | 0-1 | 9,355 | | |
| 28/09/2021 | Shrewsbury Town | Sky Bet League 1 | | Away | W | 2-1 | 4510 | Joe Jacobson 52, Ryan Tafazolli 66 | |
| 02/10/2021 | Morecambe | Sky Bet League 1 | | Home | W | 4-3 | 4161 | Daryl Horgan 50, Sam Vokes 53, Ryan Tafazolli 73, Curtis Thompson 92 | |
| 05/10/2021 | MK Dons | EFL Trophy | SGC | Away | L | 1-2 | 1320 | | |
| 09/10/2021 | Gillingham | Sky Bet League 1 | | Home | W | 2-0 | 4992 | Garath McCleary (2) Brandon Hanlan (7) | |
| 16/10/2021 | Doncaster Rovers | Sky Bet League 1 | | Away | W | 2-0 | 6134 | Anthony Stewart (2) Adebayo Akinfenwa (17) | |
| 19/10/2021 | Rotherham United | Sky Bet League 1 | | Away | D | 0-0 | 8104 | | |
| 23/10/2021 | Crewe Alexandra | Sky Bet League 1 | | Home | W | 2-1 | 4813 | | |
| 26/10/2021 | Bournemouth U-23s | Unofficial Friendly | | Home | D | 1-1 | | | |
| 30/10/2021 | Fleetwood Town | Sky Bet League 1 | | Away | D | 3-3 | 2657 | Brandon Hanlan (24) Adebayo Akinfenwa (30) Sam Vokes (50) | |
| 02/11/2021 | Ipswich Town | Sky Bet League 1 | | Home | L | 1-4 | 6943 | | |
| 06/11/2021 | Hartlepool United | F.A.Cup | 1 | Away | D | 2-2 | 4271 | Chris Forino (63) Joe Jacobson (pen 74) | |
| 09/11/2021 | Burton Albion | EFL Trophy | SGC | Home | L | 0-5 | 593 | | |
| 13/11/2021 | Portsmouth | Sky Bet League 1 | | Home | L | 0-1 | 6471 | | |
| 16/11/2021 | Hartlepool United | F.A.Cup | 1R | Home | L | 0-1 | 1582 | | |
| 20/11/2021 | Bolton Wanderers | Sky Bet League 1 | | Home | W | 1-0 | 5710 | | |
| 23/11/2021 | Plymouth Argyle | Sky Bet League 1 | | Away | W | 3-0 | 12833 | Sam Vokes (62) Anis Mehmeti (84+90) | |
| 27/11/2021 | Sheffield Wednesday | Sky Bet League 1 | | Away | D | 2-2 | 20761 | Anis Mehmeti (23) Jordan Obita (65) | |
| 07/12/2021 | Burton Albion | Sky Bet League 1 | | Home | W | 2-1 | 3602 | Brandon Hanlan (16) Garath McCleary (45) | |
| 11/12/2021 | Wimbledon | Sky Bet League 1 | | Home | D | 2-2 | 4915 | Adebayo Akinfenwa (74) Joe Jacobson (pen 96) | |
| 14/12/2021 | Kinetic Foundation Academy | BCD Friendly | | Bisham | W | 5-0 | | Tjay De Barr (2), Ali Al-Hamadi, Sullay Kaikai, Jack Wakely | |
| 29/12/2021 | Ipswich Town | Sky Bet League 1 | | Away | L | 0-1 | 26456 | | |
| 01/01/2022 | Charlton Athletic | Sky Bet League 1 | | Away | W | 1-0 | 18895 | | |
| 08/01/2022 | Sunderland | Sky Bet League 1 | | Home | D | 3-3 | 7229 | Anis Mehmeti (13) Sam Vokes (36) Joe Jacobson (98) | |
| 11/01/2022 | Bolton Wanderers | Sky Bet League 1 | | Away | W | 2-0 | 12584 | Brandon Hanlan (35) Jack Grimmer (52) | |
| 15/01/2022 | Oxford United | Sky Bet League 1 | | Home | W | 2-0 | 8005 | Curtis Thompson (33) Brandon Hanlan (60) | |
| 22/01/2022 | Morecambe | Sky Bet League 1 | | Away | L | 2-3 | 3865 | Adebayo Akinfenwa (74) Jack Grimmer (54) | |
| 24/01/2022 | Ipswich Town | BCD Friendly | | Home | L | 0-2 | | Adebayo Akinfenwa (74) Jack Grimmer (54) | |
| 29/01/2022 | MK Dons | Sky Bet League 1 | | Home | L | 0-1 | 7345 | | |
| 08/02/2022 | Shrewsbury Town | Sky Bet League 1 | | Home | D | 0-0 | 3871 | | |
| 12/02/2022 | Lincoln City | Sky Bet League 1 | | Away | D | 1-1 | 8319 | | |
| 15/02/2022 | Long Crendon | Berks & Bucks Cup | QF | Away | W | 4-0 | 1904 | Ali Al-Hamadi (20) Jack Young (51) Oli Pendlebury (79) JB Fischer (91) | |
| 19/02/2022 | Cheltenham Town | Sky Bet League 1 | | Home | D | 5-5 | 5574 | Jordan Obita (26,31) Brandon Hanlan (33) Sam Vokes (68,69) | |
| 22/02/2022 | Wigan Athletic | Sky Bet League 1 | | Home | L | 1-3 | 4826 | | |
| 26/02/2022 | Accrington Stanley | Sky Bet League 1 | | Away | L | 2-3 | 2242 | Sam Vokes (13) Sullay Kaikai (22) | |
| 01/03/2022 | Cambridge United | Sky Bet League 1 | | Home | W | 3-0 | 4083 | Anis Mehmeti (11,85) Garath McCleary (15) | |
| 05/03/2022 | Crewe Alexandra | Sky Bet League 1 | | Away | W | 3-1 | 4031 | Sam Vokes (14) Lewis Wing (55,100) | |
| 07/03/2022 | Brentford | BCD Friendly | | Away | W | 3-2 | | | |
| 12/03/2022 | Rotherham United | Sky Bet League 1 | | Home | D | 0-0 | 5742 | | |
| 15/03/2022 | Fleetwood Town | Sky Bet League 1 | | Home | W | 1-0 | 3391 | | |
| 19/03/2022 | Portsmouth | Sky Bet League 1 | | Away | D | 0-0 | 15092 | | |
| 22/03/2022 | Ascot United | Berks & Bucks Cup | S/F | Away | L | 0-0 | 1267 | | Lost 1-3 on penalties |
| 02/04/2022 | Doncaster Rovers | Sky Bet League 1 | | Home | W | 2-0 | 5943 | Garath McCleary (18) Anis Mehmeti (75) | |
| 05/04/2022 | Cambridge United | Sky Bet League 1 | | Away | W | 4-1 | 4751 | Sam Vokes (7,54) Josh Scowan (56) Garath McCleary (89) | |
| 09/04/2022 | Gillingham | Sky Bet League 1 | | Away | D | 1-1 | 4858 | | |
| 15/04/2022 | Plymouth Argyle | Sky Bet League 1 | | Home | W | 2-0 | 8181 | | |
| 18/04/2022 | Wimbledon | Sky Bet League 1 | | Away | D | 1-1 | 8508 | | |
| 23/04/2022 | Sheffield Wednesday | Sky Bet League 1 | | Home | W | 1-0 | 9005 | | |
| 30/04/2022 | Burton Albion | Sky Bet League 1 | | Away | W | 2-1 | 4440 | Sam Vokes (20) Jordan Obita (62) | |
| 05/05/2022 | MK Dons | Sky Bet League 1 | P/O S/F1 | Home | W | 2-0 | 8987 | Ryan Tafazolli (38) Sam Vokes (82) | |
| 08/05/2022 | MK Dons | Sky Bet League 1 | P/O S/F2 | Away | L | 0-1 | 13012 | | |
| 21/05/2022 | Sunderland | Sky Bet League 1 | P/O Final | Wembley | L | 0-2 | 72332 | | At Wembley |